With regard to harsh side effects sometimes perceived in bodybuilding, this principally or only occurs when estrogen levels are elevated. While oxymetholone does not itself aromatize and does not have estrogenic activity, it may be that it can interfere with estrogen metabolism. Whether that it is the cause of the problem or not, keeping estradiol levels under control keeps Anadrol similar in side effects to other oral anabolic steroids. Estradiol levels may be kept under control either by using an aromatase inhibitor such as letrozole or Arimidex, or by limiting use of aromatizing steroids such as testosterone.
It is interesting to note that oxymetholone does exhibit some tendency to convert to dihydrotestosterone in the body, although this does not occur via the 5-alpha reductase enzyme. Oxymetholone is already a dihydrotestosterone-based steroid, so no such alteration can take place. Aside from the added c-17 alpha alkylation (discussed below), oxymetholone differs from DHT only by the addition of a 2-hydroxymethylene group. This grouping can be removed metabolically, reducing oxymetholone to the potent androgen 17alpha-methyl dihydrotestosterone (mestanolone). 387 There is little doubt that this biotransformation contributes at least on some level to the androgenic nature of this steroid. Note that since 5-alpha reductase is not involved, the relative androgenicity of oxymetholone is not affected by the concurrent use of finasteride or dutasteride.
Even with the use of liver protectants and aromatase inhibitors that may help reduce estrogenic or female type side effects, they are possible.
Anadrole Before & After Pictures Gained 25 LB lean muscle ★ ★ ★ ★ ★ Gaining 13lbs in 4 weeks and staying lean while still getting stronger was something I’ve not done before! Cole W. VIEW REVIEW Gained 9 LB muscle mass ★ ★ ★ ★ ★ I used to hammer curl 25 pounds I now can do it with 40’s. My before squat was 125 I now can hit 145. Allan Y. VIEW REVIEW Increased bench press by 20 LB ★ ★ ★ ★ ☆ My max bench was 205 before the cycle. After it moved up to 225. My body has shaped up so much more than before. Brandon C. VIEW REVIEW Gained 18 lb of muscle ★ ★ ★ ★ ★ I’ve gained over 18lbs of pure muscle, my biceps have gone from 15 inches to over 18 inches. Tony E. VIEW REVIEW
A user doesn’t have to have a predisposition to certain problems to experience negative side effects associated with any anabolic androgenic steroid. Other side effects are also possible.