In the short term, the side effects can include headaches, sleeplessness, and elevated blood pressure . If you currently are under doctor’s care for high blood pressure, you should not use this drug. It can significantly increase your risk of stroke, heart disease, and heart attack. For those that do not suffer from high blood pressure, some believe the benefits when used for a short period of time such as 4 – 6 weeks, are worth it. Body builders see a significant amount of increased muscle mass in the first 3 weeks of usage. The negative side effects will remain until the user stops taking the drug.
Although I am usually not inclined to posit speculations on why a particular drug does or doesn't do something, in this case I will. Im guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body's natural hormonal system, on par with most other oral steroids , but not as bad as most injectables, and its certainly not as harsh on your lipid profile as many anabolics are