Andarine is usually used in conjunction with other arms like above, but it can be dosed anywhere from the 50-150mg day. Dosing for bulking or recaps should be 50mg or higher, but cutting should stay at 50mg. As Andarine (s4) has a short halflife, splitting up the dose to 2 or 3x a day is optimal, to keep levels in the body high.
It can also be dosed 1 hour before a workout, only on workout days and this is called Pulsing, resulting in some slight fat loss, but decent strength gains.
S4 is usually dosed on a five day on, two days off schedule (Monday to Friday on, Weekends off) to reduce the side effects affecting eyesight.
It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.