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In terms of molecular structure, synephrine has a phenethylamine skeleton, with a phenolic hydroxy - group, an alcoholic hydroxy- group, and an N-methylated amino -group. Alternatively, synephrine might be described as a phenylethanolamine with an N-methyl and p -hydroxy substituent. The amino-group confers basic properties on the molecule, whereas the phenolic -OH group is weakly acidic: the apparent (see original article for discussion) pK a s for protonated synephrine are (phenolic H) and (ammonium H). [49]

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