Primo mast cycle

Volume 23, Number 4

Original Contribution

BMP-7 Attenuates TGF-b1-Induced Fibronectin Secretion and Apoptosis of NRK-52E Cells by the Suppression of miRNA-21 147
Zhong Yu, Xu  Zai -Chun, Han  Wun-Lun , and Zhu Yun-Yun

miRNA-497 Negatively Regulates the Growth and Motility of Chondrosarcoma Cells by Targeting Cdc25A 155
Yandong Lu,  Fangguo Li, Tao Xu, and  Jie Sun

miR-544a Promotes Breast Cancer Cell Migration and Invasion Reducing Cadherin 1 Expression 165
Pengwei Lu,  Yuanting Gu , Lin Li, Fang Wang, and  Xinguang Qiu

Inhibition of Liver Carcinoma Cell Invasion and Metastasis by Knockdown of Cullin7 In Vitro and In Vivo 171
Donghui Zhang,  Genling Yang,  Xidong Li, Cheng Xu, and  Honglei Ge

Clinical Outcome in Definitive Concurrent  Chemoradiation With Weekly Paclitaxel and Carboplatin for Locally Advanced Esophageal and Junctional Cancer 183
Vanita Noronha, Kumar  Prabhash , Amit Joshi, Vijay  Maruti Patil , Sanjay  Talole ,  Dipti Nakti , Arvind  Sahu ,  Srushti Shah,  Sarbani Ghosh- Laskar ,  Prachi S.  Patil ,  Shaesta A. Mehta, Nirmala Jambhekar , Abhishek Mahajan, and  Nilendu Purandare

FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion 197
Shuang Wang,  Daqi Zhao,  Ruihua Tian,  Hailong Shi,  Xiangming Chen,  Wenzhi Liu, and Lin Wei

SIDE EFFECTS:
It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.

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